"Vioxx is a new drug that promises to effectively reduce the pain and inflammation of some types of arthritis with potentially fewer side effects. Vioxx is one of a new class of drugs known as COX-2 inhibitors. Medical researchers believe that these drugs offer a safer alternative to the millions of people at risk for ulcers and other gastrointestinal side effects from non-steroidal anti-inflammatory drugs (NSAIDs). The Arthritis Foundation believes that new medications like Vioxx will help improve the quality of life for the nearly 43 million Americans affected by arthritis by potentially reducing the side effects of needed medications. Vioxx received final approval from the Food and Drug Administration (FDA) on May 21, 1999."

How It Works:

Rofecoxib or Vioxx is a COX-2 specific inhibitor. Cyclo oxygenase compounds are found throughout the body - for example, in the nervous system and stomach. COX-2 is a type of cyclo oxygenase that produces prostaglandins that cause pain and inflammation. COX-1 is a type of cyclo oxygenase that is found in the stomach that helps protect the stomach lining. Thus, being specific for COX-2, Rofecoxib or Vioxx reduces pain and inflammation with little stomach irritation.

Side Effects:

Rofecoxib or Vioxx is generally well tolerated. It has a lower incidence of stomach side effects - irritation, ulcers, and even bleeding - than other anti inflammatory drugs.

Cautions for People:

People who have a sensitivity to other anti inflammatory drugs may be able to tolerate Rofecoxib or Vioxx, however they should use it with caution.

Drug Interactions:

While Rofecoxib or Vioxx does have a lower incidence of stomach adverse effects, care must be taken when combining it with other drugs, most notably other anti inflammatory drugs, because stomach irritation may result.