Note about Acnederm (Azelaic Acid)
While Acnederm (Azelaic Acid) is not indicated for use in treating Androgenetic alopecia, some dermatologists and specialists use and prescribe this product as part of the treatment of this condition, and there are a number of commercial solutions available which contain Azelaic acid for the treatment of Androgenetic alopecia.
No controlled studies have been conducted to see how effective it is in promoting hair growth in Androgenetic alopecia.
Description and Notes
Azelaic acid is a saturated dicaroxylic acid found naturally in wheat, rye and barley. It is effective against a number of skin conditions when applied topically in a cream formation of 20%.
Azelaic acid is used in the treatment of acne. Azelaic acid displays bacteriostatic and bactericidal properties against a variety of aerobic and anaerobic micro-organisms present on acne-bearing skin.
Azelaic acid effects the hornification process of the epidermal cells and is therefore able to exert a therapeutically positive effect on the formation of comedones (blackheads, whiteheads) which occur in acne.
Azelaic acid like Acnederm is more commonly used in the treatment of acne and other skin conditions. Recently the potential effect of using azelaic acid in the treatment of androgenetic alopecia has been looked at and discussed.
Studies carried out in France in the late 80's assessed the effects of zinc sulphate and azelaic acid on the human skin. The result of these studies demonstrated that at high concentrations zinc could completely inhibit the activity of 5 alpha reductase. Azelaic acid was also shown to be a potent inhibitor of 5 alpha reductase. Inhibition was detectable at concentrations as low as 0.2mmol/l and was complete at 3mmol/l. When zinc, vitamin b6 and azelaic acid where added together at very low concentrations which had been ineffective alone. 90% inhibition of 5 alpha reductase was achieved.
Dosage and Administration
Cosmetics may be used, but before Acnederm is applied the skin should be thoroughly cleaned with clear water or, if applicable, a mild skin-cleansing agent. Antistringent toiletries should be avoided.
Unless otherwise instructed by a doctor, Skinoren should be applied generously to the affected areas twice a day (morning and evening) and rubbed well into the skin. As a guide a daily dose of 2gm (1gm per application) will be sufficient for the treatment of the entire facial area.
In the event of excessive irritation of the skin the frequency of use of Skinoren should be reduced to once a day until the irritation ceases or the treatment should be temporarily interrupted.
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